Endocrine Abstracts

As a phytoestrogen, kaempferol plays a chemopreventive role inhibiting cancer formation and progression. In this study, chemopreventive activity of kaempferol was examined by measuring its effect on growth, epithelial-mesenchymal transition (EMT), and migration of MCF-7 breast cancer cells increased by 17β-estradiol (E2, a positive control) or triclosan (TCS), an endocrine-disrupting chemical (EDC). As an EDC, TCS is known to interfere estrogen receptor (ER) dependent pat...

Pseudohypoglycemia has been reported in patients with Raynaud’s phenomenon, peripheral vascular disease and shock and may result from increased glucose extraction by the tissues because of low capillary flow and increased glucose transit time. We present a frail and comorbid 76-year-old lady with a long standing history of Rheumatoid arthritis/systemic sclerosis/systemic lupus erythematosis overlap syndrome complicated by Raynaud’s phenomenon. She was on long-term st...

A 64 year old lady was admitted with a 2 day history of feeling generally unwell. Her relatives also reported new onset confusion over these 2 days. Her bloods showed raised inflammatory markers (CRP 110.3 mg/l, WCC 18.2×109/l) hypoalbuminemia (17 g/l), bilirubinemia (55 μmol/l) and a raised alkaline phosphatase (917 IU/l). She had recently been diagnosed with carcinoid syndrome; primary tumour situated in the terminal ileum with liver metastasis and had b...

Background: Raised blood pressure (BP) in adolescents with type 1 Diabetes Mellitus (T1DM) has been associated with adverse cardiovascular outcomes independently of raised HbA1c. It is therefore of critical importance that these patients are identified early and appropriate treatment instigated. Of concerns, studies have recognised suboptimal management of hypertension in most of these young people, allowing them to succumb to complications of diabetes with hypertension in the...

Three people (two males), with mean age (range) 65 (49–75) years, presented as emergencies with acute renal failure (AKI). They had type 2 diabetes mellitus, with mean duration 7 (2–12) years. All three were taking anti-hypertensive therapy: two were on ramipril and one on losartan and indapamide. All three were taking metformin with mean daily dose 2.6 (1.7–3.0) g. All three patients had mild renal impairment (CKD stage 3), but renal function was stable 2–...

A 64-year-old man was referred with an incidental finding of multiple bilateral thyroid cysts following CT scanning for abdominal pain. He had originally presented with an acute episode of left upper quadrant pain. CT scan of the abdomen demonstrated multiple lesions in the liver compatible with simple cysts. There were also multiple bilateral renal cysts, of which the largest was 10 cm. A small amount of retroperitoneal fluid was seen, probably as a result of a ruptured cyst....

Introduction: The study was a single-center, open label, randomized, head-to-head clinical study to compare the mucosal findings after perform esophagogastroduodenoscopy between two groups before and after use of alendronate only and enterocoating alendronate (5 mg) with calcitriol (0.5 μg) combined drug (Maxmarvil).Methods: The 33 postmenopausal healthy volunteers, aged 50–70 years (mean age: 58±5 years) without gastrointestinal symptoms ...

Prostate cancer have been most cause of cancer death to men in recent, but there are not effective treatments for this cancer. In growth of prostate cancer, steroid hormones such as androgen play a role in their growth and survival. However, endocrine disrupting chemicals (EDCs) intend to bind the hormone receptor and induce the abnormal hormone response. EDCs have potency to activate estrogen receptor (ER) and androgen receptor (AR) mediated signaling pathways, and they cause...

Introduction: Thyroid eye disease (TED) is a visually disabling and cosmetically disfiguring condition. There is a paucity of research on the psychosocial impact of TED. One of the aims of this research is to improve understanding of the extent and type of psychosocial distress experienced by TED patients.Method: 77 patients with TED were recruited (53 female, 24 male; aged between 25 and 73 years, average age=47.6±11.6 yrs; 58% Caucasian). Particip...

The pathogenesis of type 2 diabetes is explained by increment of insulin resistance and dysfunction of insulin secretion. If improvement of insulin resistance is not adequate in the early stage of diabetes especially in this country with more severe basal insulin secretion defect from the very beginning, diabetes rapidly progress to more aggressive stage with relative insulin deficiency. The most proper method of improving insulin resistance by prescription is metformin from t...